What are the most common side effects of Trelegy Ellipta?
The most common side effects of Trelegy Ellipta are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Infection in the nose or throat, sore throat, or common cold symptoms
- Lung infections, such as bronchitis or pneumonia
- Headache
- Back pain
- Joint pain
- Flu
- Symptoms of a urinary tract infection (UTI), such as painful or frequent peeing
- Oral thrush (see below)
There may be other side effects of Trelegy Ellipta that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Trelegy Ellipta?
While less common, the most serious side effects of Trelegy Ellipta are described below, along with what to do if they happen.
Reduced Adrenal Function. Long-term use of Trelegy Ellipta can cause your body’s adrenal glands to stop making as much cortisol (the stress hormone). This is known as adrenal insufficiency.This is especially a concern if you have been taking a corticosteroid by mouth, such as prednisone or methylprednisolone, and you stop it and switch to Trelegy Ellipta. Adrenal insufficiency can also get worse if your body is under stress because of fever, surgery, or trauma. Contact your healthcare provider right away if you experience the following symptoms of adrenal suppression. Do not stop using your Trelegy Ellipta.
- Low blood pressure
- Nausea or vomiting
- Weakness, tiredness, or lack of energy
Sudden Breathing Problems. Trelegy Ellipta may cause the muscles around the airways to tighten (bronchospasm) instead of relaxing, which can be serious. Stop using Trelegy Ellipta and contact your healthcare provider right away if your ability to breathe worsens right after using the medicine.
Glaucoma or Cataracts. Using Trelegy Ellipta for a long time may increase pressure inside the eye and cause or worsen narrow-angle glaucoma, which can lead to blindness. It may also increase the risk of cataracts. Tell your healthcare provider right away if you have any of the following symptoms of glaucoma or cataracts.
- Loss of vision or vision changes
- Eye pain or redness
- Severe headache or vomiting
- Seeing bright, colorful circles around lights (vision halos)
Inability to Empty Bladder (Urinary Retention). Trelegy Ellipta might make it harder to empty your bladder, especially if you already have a blockage or trouble peeing. Stop using Trelegy Ellipta and call your healthcare provider right away if you have a hard time peeing or have a weak stream, if peeing is painful, or you are peeing frequently.
Heart Effects. Trelegy Ellipta may increase your risk of certain effects on the heart, such as raising your heart rate, blood pressure, or causing an abnormal heart rhythm (arrhythmia). If you measure your blood pressure and the top number (systolic) is 180 mm Hg or higher or the bottom number (diastolic) is 120 mm Hg or higher, get medical attention right away. Also call your healthcare provider or get medical attention right away if you have chest pain, a fast or irregular heartbeat, or if you feel your heartbeat more than usual.
Increased Blood Sugar. Trelegy Ellipta may increase your blood sugar levels. Talk to your healthcare provider about how to maintain healthy blood sugar levels.
Infection. Trelegy Ellipta can increase the risk of infections, including serious infections. Call your healthcare provider if you have any of the following symptoms.
- Bumpy red rash
- Burning or stinging when you pee
- Cough or coughing up blood
- Fever, sweats, chills, or muscle aches
- Shortness of breath
- Diarrhea or stomach pain
- Weight loss
Low Potassium Level (Hypokalemia). Trelegy Ellipta can cause a low potassium level, which can be serious. Your healthcare provider will check your potassium levels, especially if you take certain other medicines. Call your healthcare provider if you have any of the following symptoms of a low potassium level.
- Weakness
- Unusual tiredness
- Muscle cramps or twitching
- Constipation
Nervous System Effects. Trelegy Ellipta may cause nervous system effects, including tremor or nervousness. Contact your healthcare provider right away if you develop these symptoms.
Oral Thrush. Trelegy Ellipta can sometimes cause the mouth and throat to become infected with a type of yeast, a condition known as oral thrush or oral candidiasis. Contact your healthcare provider if you notice any of the following symptoms of oral thrush.
- Cracking in the corners of the mouth
- Loss of taste
- Red or white patches in the mouth or throat
- Raised white spots in the mouth or throat
Pneumonia. Pneumonia is an infection of the lungs that can make it hard to breathe. Some people with COPD who use Trelegy Ellipta have developed pneumonia. Contact your healthcare provider right away if you have any of the following symptoms of pneumonia.
- Trouble breathing
- Increased mucus or change in mucus color
- Worsening cough
- Fever or chills
Severe Allergic Reactions. Trelegy Ellipta can cause allergic reactions, which can be serious. Stop using Trelegy Ellipta and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Slow Growth. In people who are still growing, such as children and adolescents, Trelegy Ellipta may slow down growth. If you use Trelegy Ellipta while you are still growing, your healthcare provider will monitor your growth rate.
Weak Bones. Using Trelegy Ellipta for a long time may cause the bones to become weaker, leading to reduced bone density (osteopenia). It may also cause a more serious condition called osteoporosis, which can cause bones to break (fracture) more easily. Your healthcare provider may monitor your bone density while you are taking Trelegy Ellipta.
